Why the study?
To investigate whether apparent tissue potassium concentration can be determined in fatty replaced muscles of FSHD patients and provide additional information to fat replacement and apparent tissue sodium concentration.
Can combined 23Na/39K MRI at 7T determine apparent tissue potassium concentration in dystrophic skeletal muscle tissue of FSHD patients compared to healthy controls?
Population
14 patients with genetically confirmed FSHD and 11 healthy controls
Comparison
FSHD patients vs healthy controls
Design
Case-control imaging study
Authors
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Supports 7T 23Na/39K MRI feasibility for aTPC in FSHD; hypothesis-generating and should not yet change practice.
Can combined 23Na/39K MRI at 7T determine apparent tissue potassium concentration in dystrophic skeletal muscle tissue of FSHD patients compared to healthy controls?
Combined 39K and 23Na MRI at 7T is feasible for determining apparent tissue potassium concentration in dystrophic skeletal muscles, providing an additional quantitative measure beyond fat replacement.
Gast et al. (2025) studied this question.
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