Why the study?
Are PPARG polymorphisms (P12A and c.1431C>T) associated with carotid atherosclerosis (IMT and TPV) in Canadian aboriginal people?
Population
161 Canadian aboriginal people
Comparison
Presence of PPARG polymorphisms vs Absence of respective PPARG polymorphisms
Design
Cross-sectional
Authors
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Should not yet inform clinical decisions in aboriginal Canadians; leaves open replication and outcome prediction in prospective cohorts.
Are PPARG polymorphisms (P12A and c.1431C>T) associated with carotid atherosclerosis (IMT and TPV) in Canadian aboriginal people?
Genetic variations in PPARG are associated with distinct carotid arterial phenotypes, suggesting the A12 allele may protect against atherogenesis.
Alshali et al. (2004) studied this question.
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