Why the study?
Type 2 diabetes, hypertension, and kidney dysfunction are known risk factors for cardiovascular disease, but their combined effect on carotid plaque remains uncertain.
Does the coexistence of decreased GFR, T2DM, and hypertension increase the prevalence and severity of carotid plaque in community-dwelling adults?
Population
3,815 community-dwelling adults in a Chinese atherosclerosis cohort
Comparison
Presence and combination of T2DM, hypertension, and decreased GFR vs none
Design
Cross-sectional analysis
Authors
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Associated with greater carotid plaque burden; leaves open causality and need for prospective studies.
Does the coexistence of decreased GFR, T2DM, and hypertension increase the prevalence and severity of carotid plaque in community-dwelling adults?
The coexistence of decreased GFR, diabetes, and hypertension is additively associated with an increased risk and burden of carotid plaque.
Che et al. (2019) studied this question.
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