Why the study?
Does practolol improve symptoms and reduce resting gradient in a patient with hypertrophic obstructive cardiomyopathy?
Does practolol improve symptoms and reduce resting gradient in a patient with hypertrophic obstructive cardiomyopathy?
High-dose oral practolol successfully relieved severe left ventricular outflow obstruction and improved symptoms in a patient with hypertrophic obstructive cardiomyopathy.
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May support practolol for symptom relief in HOCM; leaves open need for controlled trials before wider use.
The clinical and haemodynamic findings in a patient with hypertrophic obstructive cardiomyopathy and severe left ventricular outflow obstruction are presented. Treatment with an increasing dose of orally administered practolol up to a maximum of 1200 mg a day, resulted in symptomatic improvement, and abolition of the resting gradient when the patient was recatheterized six months later.
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Gamal et al. (1975) studied this question.
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