Why the study?
Does covered stent placement in the mid-left anterior descending artery reduce left ventricular outflow tract gradient and improve symptoms in a patient with hypertrophic cardiomyopathy with left ventricular outflow tract obstruction?
Does covered stent placement in the mid-left anterior descending artery reduce left ventricular outflow tract gradient and improve symptoms in a patient with hypertrophic cardiomyopathy with left ventricular outflow tract obstruction?
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Covered stent placement in the LAD to occlude septal perforators may serve as an effective alternative treatment for hypertrophic cardiomyopathy with left ventricular outflow tract obstruction when alcohol septal ablation is not feasible.
A woman in her 60s presented with progressive exertional dyspnoea, exertional chest pressure and exertional dizziness. Echocardiogram identified a 156 mm Hg left ventricular outflow tract gradient with provocation, indicating hypertrophic cardiomyopathy with left ventricular outflow obstruction-confirmed with MRI and angiogram. An alcohol septal ablation was planned but due to communication of the second septal perforator with the right ventricle and a wire-induced mid-left anterior descending artery dissection, alcohol septal ablation was not performed. Instead, a covered stent was placed in the mid-left anterior descending artery covering the origins of the third and fourth septal perforators. The left ventricular outflow tract gradient decreased from 90 to 30 mm Hg with provocation and her symptoms improved. Follow-up showed a left ventricular outflow tract gradient of 35 mm Hg with provocation and decreased symptoms.
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Pekas et al. (2022) studied this question.
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