Why the study?
Extra-skeletal Ewing sarcoma predominantly affects adolescents and young adults but can occur in older patients, leading to misdiagnosis and treatment delays.
This case highlights the importance of molecular testing such as RNA sequencing to accurately diagnose rare tumors like Extra-skeletal Ewing sarcoma in older adults, preventing misdiagnosis.
Consider EES in older adults with soft tissue tumors and cancer history; leaves open links to prior malignancy and requires larger studies.
Ewing sarcoma (ES), particularly Extra-skeletal Ewing sarcoma (EES), is a rare, aggressive tumor predominantly affecting adolescents and young adults, yet it can occur in older patients, leading to misdiagnosis and delay in treatment. The standard approach includes surgical resection, chemotherapy, and radiation therapy for unresectable disease. This case report presents a 63-year-old female patient with a history of triple-negative breast cancer, who was discovered to have a soft tissue tumor in the left medial thigh. Initially misdiagnosed as rhabdomyosarcoma, the diagnosis of EES was ultimately confirmed via RNA sequencing revealing the EWSR1-FLI1 fusion gene. She underwent neoadjuvant chemotherapy followed by radical resection of the tumor.
No takes yet. Share an insight, caveat, or question.
Ho et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: