Why the study?
Preeclampsia is the most common cause of pregnancy-related death, but its underlying cause remains unknown and lipid metabolism is altered.
Do concentrations of LPL, Apo E, and Apo C2 differ between pregnant women with and without preeclampsia?
Do concentrations of LPL, Apo E, and Apo C2 differ between pregnant women with and without preeclampsia?
Elevated levels of LPL, ApoC2, and ApoE in preeclamptic women suggest that altered lipid metabolism may serve as a marker and potential pathogenic factor in preeclampsia.
May indicate altered lipid metabolism in preeclampsia; hypothesis-generating and should not change clinical practice.
Background: Preeclampsia (PE) is a multisystemic syndrome specific to pregnancy. Although PE is the most common cause of death from pregnancy-related problems, its underlying cause is still unknown. In PE, lipid metabolism is altered. When lipids are damaged, both the mother and the foetus may be at risk. Methods: Blood samples were taken from 45 normotensive and 45 preeclamptic pregnant women. These samples were analyzed for LPL, Apo E and C2. Results: Concentrations of LPL, Apo C2 and Apo E differ significantly between preeclamptic women and pregnant controls which were higher in preeclamptic than in pregnant controls. Conclusions: In preeclamptic women, the increase in LPL, ApoC2 and Apo E concentration may serve as a marker for preeclampsia complication that which leads to worse consequences and could be a relevant factor in the pathogenesis of preeclampsia.
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Kadhim et al. (2022) studied this question.
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