Why the study?
The study was conducted to investigate the dynamic changes in lipid profiles under double filtration plasmapheresis in patients with severe hypertriglyceridemia-induced acute pancreatitis and ascertain their association with clinical prognosis.
Does double filtration plasmapheresis alter lipid profiles and correlate with hospitalization duration in patients with severe hypertriglyceridemia-induced acute pancreatitis?
Does double filtration plasmapheresis alter lipid profiles and correlate with hospitalization duration in patients with severe hypertriglyceridemia-induced acute pancreatitis?
Double filtration plasmapheresis rapidly improves lipid profiles in severe hypertriglyceridemia-induced acute pancreatitis, with post-treatment HDL levels inversely correlating with hospitalization duration.
DFPP-associated HDL rise may shorten stays in hypertriglyceridemia pancreatitis; leaves open whether RCTs confirm benefit or alter practice.
BACKGROUND: To investigate the dynamic change of lipid profile under double filtration plasmapheresis (DFPP) in severe hypertriglyceridemia-induced acute pancreatitis (sHTGP) patients and ascertain the association between these changes and the clinical prognosis. METHODS: sHTGP patients admitted within 72 h after disease onset were included, and all the patients received DFPP within 24 h after admission. Lipid profile were detected on admission, consecutive 4 days after DFPP and at discharge. RESULTS: There were 47 sHTGP patients enrolled in this study. At admission, all the parameters of lipid profile changed significantly except for low density lipoprotein. In the first day after DFPP, the serum level of TG, cholesterol and very low density lipoprotein declined significantly, while the high-density lipoprotein (HDL) as well as apoprotein A1 elevated obviously (P < 0.05). TG maintained the downward trend in the following three days and the other parameters kept steady. Linear regression analysis showed that HDL was negatively correlated with the duration of hospitalization among three adjusted models (P = 0.043, P = 0.029, P = 0.025 respectively). CONCLUSION: There was distinct fluctuation of the lipid profile upon the burst of sHTGP and the parameters changed significantly in the first day after DFPP. Among these parameters, HDL may serve as a biomarker for disease prognosis in patients with sHTGP.
No takes yet. Share an insight, caveat, or question.
Zheng et al. (2020) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: