Why the study?
Are pathogenic mutations in the LPL gene associated with hypertriglyceridemic type 2 diabetes in Chinese patients?
Population
277 Chinese patients with hypertriglyceridemic type 2 diabetes and 241 healthy control subjects
Comparison
Genetic screening for sequence changes in the… vs Healthy control subjects
Design
Case-control
Authors
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LPL missense variants may contribute to hypertriglyceridemic T2D; leaves open screening or targeted interventions pending validation.
Are pathogenic mutations in the LPL gene associated with hypertriglyceridemic type 2 diabetes in Chinese patients?
Pathogenic missense mutations in the LPL gene lead to reduced enzyme activity, which may drive a vicious cycle of hypertriglyceridemia, insulin resistance, and type 2 diabetes in Chinese patients.
Yang et al. (2003) studied this question.
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