April 12, 1994Proceedings of the National Academy of SciencesOpen Access

Effect of increasing doses of angiotensin II infused into normal and hypertensive Wistar rats on low density lipoprotein and fibrinogen uptake by aortic walls.

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Why the study?

Does angiotensin II infusion increase the uptake of LDL and fibrinogen by aortic walls in normal and hypertensive Wistar rats?

Population

Normal and spontaneously hypertensive Wistar rats

Comparison

Angiotensin II subcutaneous infusion at… vs Control rats and spontaneously hypertensive rats…

Design

Preclinical

Follow-up

6 days

Authors

LCL E Cardona-SanclementeUniversité Paris-Sud GBG. V. R. BornUniversity of London

Discussion

Member takes

Implication

Angiotensin II may enhance aortic uptake of atherogenic proteins in rats independent of pressor effects; leaves open translation to human atherosclerosis.

Structured PICO

Does angiotensin II infusion increase the uptake of LDL and fibrinogen by aortic walls in normal and hypertensive Wistar rats?

Population

Normal and spontaneously hypertensive Wistar rats

Intervention

Angiotensin II subcutaneous infusion at increasing doses for 6 days

Comparator

Control rats and spontaneously hypertensive rats without angiotensin II infusion

Outcome

Uptake of rat or human low density lipoprotein (LDL) and of human fibrinogen by aorta (measured by radioactivity of aortic walls 24 hours after i.v. injection)surrogate

Angiotensin II increases the uptake of atherogenic plasma proteins by the rat aorta, an effect that appears independent of its pressor action.

Cite This Study

Cardona-Sanclemente et al. (1994) studied this question.

synapsesocial.com/papers/6a82c4431d8eddfbf50f732c https://doi.org/10.1073/pnas.91.8.3285

Topics

Hypertension management

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Implication

Angiotensin II may enhance aortic uptake of atherogenic proteins in rats independent of pressor effects; leaves open translation to human atherosclerosis.

Effect of increasing doses of angiotensin II infused into normal and hypertensive Wistar rats on low density lipoprotein and fibrinogen uptake by aortic walls.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Effect of increasing doses of angiotensin II infused into normal and hypertensive Wistar rats on low density lipoprotein and fibrinogen uptake by aortic walls.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider