What question did this study set out to answer?

To determine whether NC/Nga mice, an established model of atopic dermatitis, develop characteristic features of human allergic asthma following ovalbumin challenge.

January 1, 2001Journal of Veterinary Medical ScienceOpen Access

Atopic NC/Nga Mice as a Model for Allergic Asthma: Severe Allergic Responses by Single Intranasal Challenge with Protein Antigen.

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Authors

TITadashi IwasakiKyoto University ATAkane TanakaNihon University AIAtsuko ItakuraYale University

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Implication

Animal study demonstrates severe asthma-like airway inflammation and hyperresponsiveness in antigen-challenged NC/Nga mice, suggesting their utility as an allergic asthma model.

Key Points

To determine whether NC/Nga mice, an established model of atopic dermatitis, develop characteristic features of human allergic asthma following ovalbumin challenge.
Immunized NC/Nga mice and BALB/c control mice with ovalbumin (OVA) and administered a single intranasal OVA challenge.
Measured plasma OVA-specific IgE, lung histopathology, airway hyperresponsiveness to acetylcholine, and pulmonary chemokine and cytokine mRNA expression.
Intranasal challenge induced marked increases in plasma OVA-specific IgE, extensive bronchial eosinophil infiltration, and epithelial mucus hyperproduction in NC/Nga mice.
Airway resistance and hyperresponsiveness to inhaled acetylcholine were markedly elevated in NC/Nga mice relative to BALB/c controls.
Delayed mRNA expression of interleukin-5, eotaxin, and macrophage inflammatory protein-1alpha occurred in lung tissue in concert with pronounced pulmonary eosinophilia.

Cite This Study

Iwasaki et al. (2001) studied this question.

synapsesocial.com/papers/6a82c4d5fdcaa17bff6d0edb https://doi.org/10.1292/jvms.63.413

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Implication

Animal study demonstrates severe asthma-like airway inflammation and hyperresponsiveness in antigen-challenged NC/Nga mice, suggesting their utility as an allergic asthma model.

Atopic NC/Nga Mice as a Model for Allergic Asthma: Severe Allergic Responses by Single Intranasal Challenge with Protein Antigen.

Discussion

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Implication

Key Points

Cite This Study

Atopic NC/Nga Mice as a Model for Allergic Asthma: Severe Allergic Responses by Single Intranasal Challenge with Protein Antigen.

Discussion

Member takes

Implication

Key Points

Cite This Study

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