The GoSlo-SR family of anthraquinone analogues provides a new scaffold for the design of efficacious BK channel openers.
GoSlo-SR anthraquinones offer a new BK opener scaffold in animal models; leaves open translation to cardiovascular therapy.
Opening up ion channels: We synthesised a series of anthraquinone analogues, called the GoSlo-SR family. Their effects on bladder smooth muscle BK channels were examined and, as shown, shifted voltage dependent activation >-100 mV (at 10 μM). They were more efficacious than NS11021 and could provide a new scaffold for the design of efficacious BK openers.
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Roy et al. (2012) studied this question.
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