Cohort study reveals distinct bile acid metabolome oscillations in individuals with obesity undergoing surgery versus dieting, highlighting specific bile acids as promising targets for drug therapy.
Bile acids (BA) are supposed to cause metabolic alterations after bariatric surgery (BS). Here we report the longitudinal dynamics of the human BA metabolome by LC-MS/MS after BS versus low calory diet (LCD) in two obesity cohorts over 12 months. Rapid and persistent oscillations of 23 BA subspecies could be identified with highly specific patterns in BS vs. LCD. TCDCA, GLCA, and TLCA represent most promising candidates for drug development.
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Schmid et al. (2024) studied this question.
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