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PURPOSE: To determine whether amniotic membrane homogenate is as effective in healing corneal damage as amniotic membrane transplantation in a rabbit model. METHOD: The rabbits were divided into three groups. The cornea of one eye in each rabbit was incised resulting in a defect of approximately 8 mm in diameter. Amniotic membrane transplantation was performed in the first group, and amnion homogenate was administered four times a day in the second group. The third group was the control group. RESULTS: There were no differences in the diameter of the defects and the rate of corneal growth between the amnion transplant group and the amnion homogenate group. CONCLUSION: Amnion homogenate is as effective as transplanted amniotic membrane in promoting corneal healing in a rabbit model.
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Guo et al. (2011) studied this question.
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