Why the study?
Does TIMP-1 gene deletion affect myocardial remodeling after discrete radiofrequency injury in mice?
Population
Wild-type (WT, 8-12 wk, 129SVE) and age-matched TIMP-1 gene-deficient (timp-1(-/-)) mice
Comparison
Discrete myocardial lesions created on the left… vs Age-matched, nonablated mice used as reference…
Design
Preclinical
Follow-up
28 days
Authors
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Hypothesis-generating for TIMP-1 modulation in myocardial repair; leaves open translation to clinical scar modulation strategies.
Does TIMP-1 gene deletion affect myocardial remodeling after discrete radiofrequency injury in mice?
TIMP-1 gene deletion leads to more extensive postinjury myocardial remodeling and scar expansion following discrete radiofrequency injury in mice.
Mukherjee et al. (2004) studied this question.
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