Chemical synthesis demonstrates total synthesis of (−)-lycorine and (−)-2-epi-lycorine via an asymmetric cascade, indicating a rapid route to chiral cyclohexane derivatives.
Total syntheses of (-)-lycorine and (-)-2-epi-lycorine were accomplished using chiral ligand-controlled asymmetric cascade conjugate addition methodology, which enables the formation of two C-C bonds and three stereogenic centers in one pot to give synthetically useful chiral cyclohexane derivatives.
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Yamada et al. (2009) studied this question.
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