Key result
Metoprolol treatment for 1 year improved survival in rats with severe aortic regurgitation compared to no treatment (60% vs 35%; P=0.028).
Why the study?
Does metoprolol improve survival and LV remodeling in rats with severe aortic regurgitation?
Population
40 Wistar rats with severe aortic valve regurgitation (AR)
Comparison
Metoprolol (25 mg.kg(-1).day(-1)) for 1 year vs Untreated for 1 year
Design
Preclinical
Follow-up
1 year
Authors
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Supports beta-blocker investigation in AR; hypothesis-generating in rats and should not change practice.
Does metoprolol improve survival and LV remodeling in rats with severe aortic regurgitation?
Absolute Event Rate: 60% vs 35%
p-value: p=0.028
Long-term metoprolol treatment improved 1-year survival and attenuated adverse LV remodeling in a rat model of severe aortic regurgitation.
Plante et al. (2008) studied severe aortic valve regurgitation (n=40). metoprolol vs. untreated was evaluated on Survival at 1 year (p=0.028). Metoprolol treatment for 1 year improved survival in rats with severe aortic regurgitation compared to no treatment (60% vs 35%; P=0.028).
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