February 1, 2002Arteriosclerosis Thrombosis and Vascular BiologyOpen Access

Inhibition of Platelet Glycoprotein Ib, Glycoprotein IIb/IIIa, or Both by Monoclonal Antibodies Prevents Arterial Thrombosis in Baboons

View Full Paper

Ask AI

Bookmark

Why the study?

Does inhibition of platelet GP Ib, GP IIb/IIIa, or both prevent arterial thrombosis in a baboon model of femoral artery stenosis?

Population

Baboon model of femoral artery stenosis with platelet-mediated thrombosis producing cyclic flow reductions

Design

Preclinical

Authors

DWDongmei WuXi'an University of Science and Technology MMMuriel MeiringNational Health Laboratory Service HKHarry F. KotzéUniversity of the Free State

Discussion

Member takes

Implication

GP Ib inhibition strategies merit human translation studies; leaves open clinical efficacy and bleeding safety in arterial thrombosis.

Structured PICO

Does inhibition of platelet GP Ib, GP IIb/IIIa, or both prevent arterial thrombosis in a baboon model of femoral artery stenosis?

Population

Baboon model of femoral artery stenosis (modified Folts model) with platelet-mediated thrombosis producing cyclic flow reductions (CFRs)

Intervention

Monoclonal antibodies 6B4-Fab (anti-GP Ib) at 0.6 or 2 mg/kg, MA-16N7C2 (anti-GP IIb/IIIa) at 0.1 or 0.3 mg/kg, or their combination (0.6 mg/kg 6B4-Fab + 0.1 mg/kg MA-16N7C2)

Outcome

Reduction in cyclic flow reductions (CFRs) and bleeding timesurrogate

Inhibition of platelet GP Ib alone or in combination with a low-dose GP IIb/IIIa blocker prevents arterial thrombosis without increasing bleeding time in a baboon model.

Cite This Study

Wu et al. (2002) studied this question.

synapsesocial.com/papers/6a82d15a3e02825336d11ceb https://doi.org/10.1161/hq0202.102321

View Full Paper

Ask AI

Bookmark

Inhibition of Platelet Glycoprotein Ib, Glycoprotein IIb/IIIa, or Both by Monoclonal Antibodies Prevents Arterial Thrombosis in Baboons

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Inhibition of Platelet Glycoprotein Ib, Glycoprotein IIb/IIIa, or Both by Monoclonal Antibodies Prevents Arterial Thrombosis in Baboons

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider