Key result
Maternal reduced protein diet during pregnancy and lactation significantly increased fed-state plasma adrenaline concentrations in 12-week-old male rat offspring (1.42 vs 0.65 nmol/l; P<0.005).
Population
12-week-old male offspring of rat dams
Comparison
Reduced protein diet fed to rat dams during… vs Control diet
Design
Preclinical
Follow-up
12 weeks (age of offspring)
Authors
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Indicates developmental programming of sympathetic activity in rats; leaves open human cardiometabolic relevance.
Absolute Event Rate: 1.42% vs 0.65%
p-value: p=< 0.005
Maternal protein restriction during pregnancy and lactation leads to long-term alterations in catecholamine metabolism and adrenoceptor expression in adult rat offspring.
Petry et al. (2000) studied Early growth restriction. Maternal reduced protein diet vs. Control diet was evaluated on Plasma adrenaline concentrations in the fed state (p=< 0.005). Maternal reduced protein diet during pregnancy and lactation significantly increased fed-state plasma adrenaline concentrations in 12-week-old male rat offspring (1.42 vs 0.65 nmol/l; P<0.005).
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