Clitoria Ternatea as a Potential Herb in Polycistic Ovary Syndrome

PCOS (Polycystic Ovary Syndrome) is a hormonal sickness that impacts ladies of reproductive age. It is characterized by irregular menstrual cycles, high levels of androgens (male hormones), and the development of small cysts on the ovaries PCOS can lead to various health problems, including infertility, insulin resistance, obesity, chronic inflammation, and metabolic disorders. These conditions can increase the risk of cardiovascular disease, heart disease, stroke, and liver damage (Vanky&Lvvik, 2020). The use of certain medications for PCOS treatment can also have side effects on liver health. Therefore, finding effective solutions to manage PCOS and its associated complications is crucial (Garad&Teede, 2020). Inflammation and oxidative strain a substantial function within side the improvement and development of PCOS. Chronic low-grade irritation can disrupt the improvement of ovarian follicles and intervene with ovulation. It can also contribute to insulin resistance, which further exacerbates the hormonal imbalance in PCOS. Oxidative stress, which takes place whilst there's an imbalance among the manufacturing of free radicals and the body's antioxidant defenses, can damage ovarian cells, and impair follicle development. It can also contribute to the formation of ovarian cysts and increase the risk of complications associated with PCOS Recent research has also explored the role of gut microbiota in PCOS. Disruption of the gut microbiota balance, known as dysbiosis, can affect hormonal regulation and contribute to inflammation and metabolic dysfunction Clitoriaternatea extract has shown potential in modulating gut microbiota and improving overall hormonal balance Clitoriaternatea, also known as butterfly pea flower, has been studied for its potential therapeutic effects in PCOS. It contains compounds such as flavonoids, alkaloids, saponins, and tannins (Gejalakshmi.S&Harikrishnan, 2023), which have antioxidant and anti-inflammatory properties Abstract: Clitoriaternatea (CT) is an herbal plant that has the potential as a therapeutic agent to manage polycystic ovarian syndrome (PCOS). CT has antioxidant and anti-inflammatory properties that can help reduce inflammation, oxidative stress, and metabolic dysfunctions associated with PCOS. In this study, we conducted a systematic review of relevant research articles on the bioactivity potential of CT as a herbal drug candidate for PCOS. We searched research articles in Indonesian and English published over the last five years (2019)(2020)(2021)(2022)(2023) through three databases: PubMed, ScienceDirect, and Google Scholar. We use established inclusion and exclusion criteria to select suitable articles. Out of 24 research articles included in our systematic review, we found that CT has potential as an antidiabetic, antiglucose, anticholesterol, antiobesity, anti-inflammatory, hepatoprotective, and antidepressant agent. Based on our systematic review, CT shows potential as a therapeutic agent for managing PCOS symptoms. The antioxidant and anti-inflammatory properties of CT can help reduce inflammation, oxidative stress, and metabolic dysfunctions associated with PCOS. However, further research is needed to validate these findings and evaluate the effectiveness of CT in clinical settings.