Biological effect of the Total Aqueous Extract of Desmodium Adscendens Leaves, an Blood Cells after Inducing Hepatotoxicity in Rats

: The antihepatotoxicity effects of the total aqueous extract of the leaves of Desmodium adscendens were evaluated at doses of 100, 200 and 400 mg/kg BW on the number of blood cells in the model of hepatitis induction with paracetamol in rats. Six groups of six rats are constituted. The group 1 received distilled water;the group 2,the paracetamol 200 mg/kg B;the group3,the paracetamol 200 mg/kg BW and vitamin C 100 mg/kg BW;the group 4, paracetamol 200 mg/kg BW and the extract 100 mg/kg BW;the group 5,the paracetamol 200 mg/kg BW and the extract 200 mg/kg BW and the group 6,the paracetamol 200 mg/kg BW and the extract 400 mg/kg BW. The solutions were administered by gavage for 30 days, the first fortnight for the induction of hepatitis and the second fortnight for its treatment. Blood samples were taken on the 2nd, 17th and 32nd days. The results show that the total aqueous extract and vitamin C lead to a dose-dependent and significant inhibition of the action of paracetamol. The total aqueous extract normalizes and stabilizes the number of defense blood cells. These studies showed the hepatoprotective through a stabilization of the number of blood cells bythe total aqueous extract of Desmodium adscendensleaves.