Key result
A potassium shift > 1 mmol/l during hemodialysis significantly increased periodic repolarization dynamics compared to shifts ≤ 1.0 mmol/l (delta PRD 2.82 vs. -2.08, p=0.006).
Why the study?
Patients with end-stage kidney disease are at high risk for arrhythmias and sudden cardiac death, particularly linked to potassium shifts during hemodialysis, but risk stratification methods remain lacking.
Does large potassium shift during hemodialysis increase periodic repolarization dynamics (PRD) in patients with end-stage kidney disease?
Observational (n=18)
Does large potassium shift during hemodialysis increase periodic repolarization dynamics (PRD) in patients with end-stage kidney disease?
Large potassium shifts during hemodialysis are associated with increased sympathetic activity-associated repolarization instability, which may contribute to the risk of malignant arrhythmias in this population.
Potassium shifts >1 mmol/l during hemodialysis may heighten arrhythmia risk; leaves open whether minimizing shifts improves outcomes in ESKD.
BACKGROUND: Patients with end-stage kidney disease are at high risk for the development of arrhythmias and sudden cardiac death (SCD). This has been especially attributed to large potassium shifts during hemodialysis (HD), and malignant arrhythmias are closely linked to dysfunction of the autonomic nervous system. Nevertheless, there is still a lack of methods for risk stratification in these patients. METHODS: In the present pilot study we investigated changes of the novel ECG-based biomarker periodic repolarization dynamics (PRD) mirroring the effect of efferent sympathetic nervous activity on the ventricular myocardium in 18 patients undergoing routine hemodialysis. High-resolution ECGs were recorded throughout the dialysis and PRD values were calculated out of 30 min intervals at the start and the end of dialysis. RESULTS: We detected a clear correlation between the intradialytic potassium shift and the increase in PRD levels (Spearman correlation coefficient R = 0.62, p = 0.006). Patients with a potassium shift > 1 mmol/l showed significantly increased levels of PRD at the end of dialysis when compared to patients with potassium shifts ≤ 1.0 mmol/l [delta PRD 2.82 (IQR 2.13) vs. - 2.08 (IQR 3.60), p = 0.006]. Spearman analysis showed no significant correlation between PRD changes and fluid removal (R = - 0.23, p = 0.36). CONCLUSIONS: We provide evidence that large potassium shifts during HD enhance sympathetic activity-associated repolarization instability. This could facilitate the occurrence of malignant arrhythmias, and PRD measurements might serve as a non-invasive monitoring tool in HD patients in future.
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Schüttler et al. (2020) conducted an observational in End-stage kidney disease (n=18). Potassium shift > 1 mmol/l vs. Potassium shift ≤ 1.0 mmol/l was evaluated on Change in periodic repolarization dynamics (delta PRD) at the end of dialysis (p=0.006). A potassium shift > 1 mmol/l during hemodialysis significantly increased periodic repolarization dynamics compared to shifts ≤ 1.0 mmol/l (delta PRD 2.82 vs. -2.08, p=0.006).
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