Metabolism of normal and tumour tissue

have repeated a number of observations made by ourselves on respiratory quotients of various isolated tissues [Dickens and Simer, 1930, 2; 1931, 2; Dickens and Greville, 1933, 1, 2; 1935].While duplicating many of our results they state that in some cases "important differences from their findings have been observed".On these differences they base a fundamental criticism of our work on metabolism.The most striking difference reported was in the case of rat-brain cortex,where Elliott and Baker report a mean R.Q. 0-86 (extremes 0.93-0.78).Our results were much higher being in the region of unity, thus supporting the view held by nearly all workers that in brain the oxidation of carbohydrate prepon- derates [