Population
Small superfused trabeculae (diameter 0.3 mm) of beating guinea pig ventricle
Comparison
3 microM norepinephrine (NE) vs Absence of norepinephrine
Design
Preclinical
Follow-up
7 minutes of exposure
Authors
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NE modestly raises aiNa in guinea pig myocytes; leaves open relevance to human sympathetic effects on excitability or arrhythmias.
Norepinephrine induces a small increase in intracellular sodium activity and stimulates the Na(+)-K+ pump in guinea pig ventricular muscle.
Wilde et al. (1991) studied this question.
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