Key result
In patients with left ventricular systolic dysfunction, a higher apical area index measured by cardiac magnetic resonance was independently associated with the presence of left ventricular thrombus (OR 1.51).
Why the study?
Structural changes altering LV apex size and shape may predict LV thrombus in LV systolic dysfunction, but definite evidence was lacking.
Does apical area index predict left ventricular thrombus in patients with systolic dysfunction?
Population
150 patients with LV systolic dysfunction (LVEF < 40%)
Comparison
30 patients with LV thrombus vs 120 patients without thrombus
Design
Case-control cardiac magnetic resonance study
Authors
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May refine CMR-based LV thrombus risk assessment in systolic dysfunction; hypothesis-generating and requires prospective validation before practice change.
Case-Control (n=150)
No
Does apical area index predict left ventricular thrombus in patients with systolic dysfunction?
Odds Ratio: 1.51 (95% CI 1.23–1.84)
p-value: p=<0.0001
Apical area index derived from CMR is a novel, independent predictor of LV thrombus in patients with systolic dysfunction.
Kaolawanich et al. (2019) conducted a case-control in Left ventricular systolic dysfunction (n=150). Apical area index was evaluated on Left ventricular thrombus (OR 1.51, 95% CI 1.23-1.84, p=<0.0001). In patients with left ventricular systolic dysfunction, a higher apical area index measured by cardiac magnetic resonance was independently associated with the presence of left ventricular thrombus (OR 1.51).
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