What question did this study set out to answer?

To develop a structural and molecular fusion MRI nanoprobe capable of differentiating malignant tumors from benign lesions and providing subsequent chemodynamic therapy.

February 9, 2023ACS Nano

Structural and Molecular Fusion MRI Nanoprobe for Differential Diagnosis of Malignant Tumors and Follow-Up Chemodynamic Therapy

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Authors

WYWeitao YangTongji University CDCuijun DengShanghai Center for Brain Science and Brain-Inspired Technology XSXiudong ShiShanghai Public Health Clinical Center

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Implication

Preclinical study demonstrates dual-mode structural and molecular MRI differentiation of malignant tumors using an ATP-responsive nanoprobe, indicating potential for one-stop precision oncology.

Key Points

To develop a structural and molecular fusion MRI nanoprobe capable of differentiating malignant tumors from benign lesions and providing subsequent chemodynamic therapy.
Engineered core-shell nanoparticles (FFT NPs) containing a magnetic Fe3O4 core and a paramagnetic iron-tannic acid (Fe-TA) shell utilizing magnetic resonance tuning effects.
Evaluated dual T1/T2 imaging capabilities, measuring always-on T2 signals for structural imaging and ATP-triggered T1 signals for molecular imaging in malignant 4T1 and benign L929 tumor models.
Assessed chemodynamic therapeutic potential by measuring catalytic hydrogen peroxide conversion to reactive oxygen species by dissociated nanoparticles.
FFT NPs provided always-on inert T2 contrast for structural MRI while activating T1 contrast specifically in the presence of tumor-overproduced ATP.
The ratiometric molecular-to-structural MRI signal intensity enabled clear differential diagnosis between malignant 4T1 tumors and benign L929 fibroblast tumors.
Dissociated FFT NPs catalyzed hydrogen peroxide conversion within 4T1 tumors to generate reactive oxygen species for chemodynamic therapy.

Cite This Study

Yang et al. (2023) studied this question.

synapsesocial.com/papers/6a82da3d92c19701ea21eba7 https://doi.org/10.1021/acsnano.2c12874

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Implication

Preclinical study demonstrates dual-mode structural and molecular MRI differentiation of malignant tumors using an ATP-responsive nanoprobe, indicating potential for one-stop precision oncology.

Structural and Molecular Fusion MRI Nanoprobe for Differential Diagnosis of Malignant Tumors and Follow-Up Chemodynamic Therapy

Discussion

Member takes

Implication

Key Points

Cite This Study

Structural and Molecular Fusion MRI Nanoprobe for Differential Diagnosis of Malignant Tumors and Follow-Up Chemodynamic Therapy

Discussion

Member takes

Implication

Key Points

Cite This Study

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