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August 1, 2000Journal of Cardiovascular Pharmacology

Inhibition of the ER-Kinase Cascade by PD98059 and UO126 Counteracts Ischemic Preconditioning in Pig Myocardium

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Why the study?

Does inhibition of the ER-kinase cascade by PD98059 and UO126 counteract ischemic preconditioning in pig myocardium?

Population

Anesthetized, ventilated, open-chested, male pigs undergoing an ischemic preconditioning protocol

Comparison

Intramyocardial infusion of MEK 1/2 inhibitors… vs Solvent infusion with ischemic preconditioning

Design

Preclinical

Follow-up

60 minutes of reperfusion after 40 minutes of index ischemia

Authors

CSClaudia StrohmMax Planck Institute for Heart and Lung ResearchMBMiroslav Barančı́kSlovak Academy of SciencesMHMarie-Luise v. Br hlMax Planck Institute for Heart and Lung Research

Discussion

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Overview

Should not change clinical practice; leaves open ERK modulation for human ischemic preconditioning.

Structured PICO

Does inhibition of the ER-kinase cascade by PD98059 and UO126 counteract ischemic preconditioning in pig myocardium?

P
Population
Anesthetized, ventilated, open-chested, male pigs undergoing an ischemic preconditioning protocol
I
Intervention
Intramyocardial infusion of MEK 1/2 inhibitors PD98059 (PD) and UO126 (UO), and systemic UO126, before ischemic preconditioning and during reperfusion phases
C
Comparator
Solvent infusion (control conditions) with ischemic preconditioning
O
Outcome
Infarct size (infarct area/risk area)surrogate

Inhibition of the ERK cascade by PD98059 and UO126 completely abolishes the cardioprotective effects of ischemic preconditioning in a porcine model.

Cite This Study

Strohm et al. (2000) studied this question.

synapsesocial.com/papers/6a82db50979d337bd4441876https://doi.org/10.1097/00005344-200008000-00012
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