What question did this study set out to answer?

To examine the role of biological resilience across molecular, physiological, and psychological domains in managing, preventing, and slowing the progression of age-associated chronic diseases.

December 17, 2025Frontiers in PhysiologyOpen Access

Biological resilience as a crucial determinant in preventing age-associated chronic diseases

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Authors

AAAmjad Islam AmjadUniversity of Lahore BSBisma Sajjad SheikhUniversity of the Punjab SASarfraz AslamUnited Nations Institute for Training and Research

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Implication

Narrative review demonstrates that biological resilience mitigates age-associated chronic disease, indicating a vital role for adaptive recovery over damage accumulation.

Key Points

To examine the role of biological resilience across molecular, physiological, and psychological domains in managing, preventing, and slowing the progression of age-associated chronic diseases.
Conducted a qualitative narrative review searching databases including PubMed and Scopus for literature published between 2020 and 2025 using terms related to biological resilience, ageing, and disease prevention.
Critically appraised empirical studies, clinical trials, and reviews focusing on biological and psychological resilience mechanisms in older adults.
Synthesized findings thematically across measurement methodologies, mechanistic disease pathways, and multi-modal intervention strategies.
Biological resilience functions as an integrated network spanning cellular repair (DNA repair, autophagy, mitochondrial dynamics), systemic reserve, and psychological adaptation to preserve homeostasis.
Erosion of adaptive capacity and homeostatic recovery across interconnected physiological layers directly predisposes individuals to cardiovascular disease, neurodegeneration, metabolic dysfunction, and frailty.
Multi-modal interventions—ranging from senolytics and rapamycin analogs to functional physical testing, psychological coping programs, and climate-adaptive measures—support reserve preservation.

Cite This Study

Amjad et al. (2025) studied this question.

synapsesocial.com/papers/6a82dc51d5d5076d1fb2920b https://doi.org/10.3389/fphys.2025.1741426

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Implication

Narrative review demonstrates that biological resilience mitigates age-associated chronic disease, indicating a vital role for adaptive recovery over damage accumulation.

Biological resilience as a crucial determinant in preventing age-associated chronic diseases

Discussion

Member takes

Implication

Key Points

Cite This Study

Biological resilience as a crucial determinant in preventing age-associated chronic diseases

Discussion

Member takes

Implication

Key Points

Cite This Study

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