April 1, 1984Circulation ResearchOpen Access

The role of cardiac receptor and arterial baroreceptor reflexes in control of the circulation during acute change of blood volume in the conscious rabbit.

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Population

7 conscious rabbits

Comparison

Acute, graded, isohemic change of blood volume… vs Different reflex states

Design

Preclinical

Authors

JLJohn LudbrookSouth Australia Pathology WGWilliam F. GrahamMote Marine Laboratory

Discussion

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Implication

Animal data show negative baroreflex interaction during volume shifts; leaves open relevance to human cardiovascular homeostasis.

Structured PICO

Population

7 conscious rabbits

Intervention

Acute, graded, isohemic change of blood volume over the range +/- 27% under different reflex conditions (intrapericardial 2% procaine, surgical baroreceptor denervation)

Comparator

Different reflex states (both present, only arterial baroreceptor present, only cardiac receptor present, both absent)

Outcome

Right atrial pressure, arterial pressure, systemic vascular resistance, cardiac output, and heart ratesurrogate

Arterial baroreceptors and cardiac receptors both play important roles in moderating acute blood volume changes in conscious rabbits, but their combined effects are diminished by negative interactions.

Cite This Study

Ludbrook et al. (1984) studied this question.

synapsesocial.com/papers/6a82dca9032e48224a10c220 https://doi.org/10.1161/01.res.54.4.424

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Bookmark

The role of cardiac receptor and arterial baroreceptor reflexes in control of the circulation during acute change of blood volume in the conscious rabbit.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The role of cardiac receptor and arterial baroreceptor reflexes in control of the circulation during acute change of blood volume in the conscious rabbit.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider