Key result
Short sleep duration (<6 hours/day) was associated with a significantly increased risk of CAD-related mortality (HR 5.20) and new-onset myocardial infarction (HR 2.67) compared to 6-8 hours of sleep.
Why the study?
Does abnormal sleep duration (<6 hours or >8 hours) increase the risk of new-onset myocardial infarction and CAD-related deaths in patients with coronary artery disease?
Cohort (n=816)
Yes
Does abnormal sleep duration (<6 hours or >8 hours) increase the risk of new-onset myocardial infarction and CAD-related deaths in patients with coronary artery disease?
Hazard Ratio: 5.2 (95% CI 2.53–10.68)
Absolute Event Rate: 12.8% vs 2.4%
p-value: p=<0.001
Both short (<6 hours) and long (>8 hours) sleep durations are associated with an elevated risk of CAD-related mortality, and short sleep duration is additionally associated with increased risk of new-onset myocardial infarction in patients with CAD.
Short and long sleep may elevate CAD mortality risk; leaves open whether sleep modification alters MI or mortality outcomes.
Background Coronary artery disease (CAD) is highly prevalent and fatal worldwide. In China, particularly in the southwest region, the association between CAD and sleep duration remains insufficiently understood. This study aims to investigate outcomes among CAD patients with varying sleep duration. Methods In a Southwest Chinese cohort, patients with CAD were categorized into three sleep duration groups: <6 hours, 6–8 hours, and >8 hours. Over a four-year follow-up, the endpoint including new-onset myocardial infarction and CAD-related deaths was recorded. The Fine-Gray model was employed to evaluate the estimated marginal occurrence probability of the target event. Additionally, Kaplan-Meier estimation and Cox regression analysis were conducted to further investigate the association between sleep duration and outcomes. Results The study enrolled 816 residents with CAD, who had an average age of 69.2 ± 8.3 years old, of whom 40.2% were male. Across the three sleep duration groups (6-8h, <6h, and >8h), the hazard ratios (HRs) with 95% confidence interval for new-onset myocardial infarction were: 1.00 (reference), 2.67 (1.57-4.55) ( P < 0.001), and 0.98 (0.30-3.21) ( P =0.970). For CAD-related mortality, the HRs were: 1.00 (reference), 5.20 (2.53-10.68) ( P < 0.001), and 5.02 (1.59-15.80) ( P =0.006). This trend was consistently observed in both the Fine-Gray model and subgroup analyses. Conclusions Both short (<6 hours/day) and long (>8 hours/day) sleep duration were linked to an elevated risk of cardiac mortality among CAD patients in Southwest China. Short sleep duration was also found to be associated with high myocardial infarction risk.
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Ma et al. (2025) conducted a cohort in Coronary artery disease (CAD) (n=816). Short sleep duration (<6 hours/day) vs. 6-8 hours/day of sleep was evaluated on CAD-related mortality (HR 5.20, 95% CI 2.53-10.68, p=<0.001). Short sleep duration (<6 hours/day) was associated with a significantly increased risk of CAD-related mortality (HR 5.20) and new-onset myocardial infarction (HR 2.67) compared to 6-8 hours of sleep.
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