Key result
Current smoking in men is associated with significantly lower plasma adiponectin levels compared to never-smokers (5.3 vs 6.5 microg/mL; P=0.01).
Why the study?
Does smoking reduce adiponectin concentration in men?
Population
331 male subjects, 5 male never-smokers, and cultured mouse 3T3-L1 adipocytes
Comparison
Smoking, and in vitro exposure to H2O2 and… vs Never-smokers, baseline before smoking, and…
Design
Cross-sectional
Follow-up
12 hours (for acute exposure test)
Authors
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Association in cross-sectional data should not change practice; leaves open whether smoking lowers adiponectin or affects cardiovascular risk in men.
Cross-Sectional (n=331)
Does smoking reduce adiponectin concentration in men?
Absolute Event Rate: 5.3% vs 6.5%
p-value: p=0.01
Smoking is associated with lower adiponectin concentrations in men, likely mediated by direct inhibition of adiponectin expression in adipocytes.
Iwashima et al. (2005) conducted a cross-sectional in Hypoadiponectinemia (n=331). Smoking vs. Never-smokers was evaluated on Plasma adiponectin concentration (p=0.01). Current smoking in men is associated with significantly lower plasma adiponectin levels compared to never-smokers (5.3 vs 6.5 microg/mL; P=0.01).
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