Key result
General anaesthetic agents influence regional coronary control through changes in metabolic demand and suppression of autonomic influence, which must be accounted for in anaesthetized models.
The effects of anesthesia must be considered when interpreting results from anesthetized models of coronary control due to their influence on metabolic and neural regulatory mechanisms.
Answers are grounded in this paper and cite their sources.
Anaesthetic effects require caution when interpreting coronary model data; leaves open translation to awake clinical physiology.
The regional coronary circulation is under the control of local metabolic and myogenic factors, but is also influenced by autonomic systems, including sympathetic and parasympathetic nerves. 2. General anaesthetic agents influence not only local control through changes in metabolic demand, but also neural control through suppression of autonomic influence. 3. Anaesthetic agents have differing effects on reflex control systems, which are dependent on coronary territory and ventricular rate. 4. Effects of anaesthesia should be taken into account when interpreting results in anaesthetized models of coronary control.
No takes yet. Share an insight, caveat, or question.
Cottee et al. (2000) conducted a review in Coronary control mechanisms. General anaesthetic agents was evaluated on Regional coronary control mechanisms. General anaesthetic agents influence regional coronary control through changes in metabolic demand and suppression of autonomic influence, which must be accounted for in anaesthetized models.
Synapse has enriched 10 related papers. Consider them for comparative context: