Key result
The combined assessment of AMH and ANGPTL8 accurately identified decreased ovarian reserve in infertile patients, demonstrating a sensitivity of 94.0%, specificity of 95.9%, and an AUC of 0.988.
Why the study?
The study was conducted to evaluate the combined diagnostic utility of anti-Müllerian hormone and angiopoietin-like protein 8 for assessing ovarian function in infertile patients.
Does the combined assessment of AMH and ANGPTL8 improve the evaluation of ovarian function in infertile patients?
Observational (n=213)
No
Does the combined assessment of AMH and ANGPTL8 improve the evaluation of ovarian function in infertile patients?
Effect estimate: AUC 0.988
The combined assessment of AMH and ANGPTL8 provides high diagnostic accuracy for evaluating ovarian reserve in infertile patients.
Should not yet change ovarian reserve assessment in infertility; leaves open whether combined AMH and ANGPTL8 improves outcomes.
BACKGROUND: This study aims to explore the value of anti-Müllerian hormone (AMH) in combination with angiopoietin-like protein 8 (ANGPTL8) in evaluating the ovarian function of infertile patients. METHODS: A total of 213 infertile patients who sought treatment in our hospital from January 2023 to July 2024 were included. Transvaginal color Doppler ultrasound assessed antral follicle count and ovarian reserve. Patients were divided into a0 control group (116 cases with normal ovarian reserve) and a research group (97 cases with decreased ovarian reserve). Serum levels of AMH, ANGPTL8, and sex hormones were measured for all patients, and results were compared between groups to analyze the combined assessment's value. RESULTS: In the control group, AMH levels were (4.44±2.36) ng/ml, ANGPTL8 (17.81±7.79) ng/ml, and estradiol (E2) (37.21±17.78) pg/ml. In the research group, AMH was (0.64±0.61) ng/ml, ANGPTL8 (12.04±5.04) ng/ml, and E2 (32.80±10.10) pg/ml. The research group showed significantly lower AMH, ANGPTL8, and E2 levels (P<0.05) and higher FSH and LH levels (P<0.001). The combined AMH and ANGPTL8 assessment demonstrated a sensitivity of 94.0%, specificity of 95.9%, and an area under the curve of 0.988. CONCLUSION: The combined assessment of AMH and ANGPTL8 holds significant value in evaluating ovarian function in infertile patients.
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Du et al. (2025) conducted an observational in Infertility with decreased ovarian reserve (n=213). Decreased ovarian reserve vs. Normal ovarian reserve was evaluated on Combined diagnostic utility of AMH and ANGPTL8 for evaluating ovarian function (AUC 0.988). The combined assessment of AMH and ANGPTL8 accurately identified decreased ovarian reserve in infertile patients, demonstrating a sensitivity of 94.0%, specificity of 95.9%, and an AUC of 0.988.
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