Key result
Recombinant CSFV harboring amino acid substitutions W871T, W875D, and V878T in the E2 glycoprotein was completely attenuated in swine and protected animals against virulent challenge at 21 days.
Alteration of a putative fusion peptide in the E2 glycoprotein of classical swine fever virus attenuates the virus in swine and provides protection against wild-type challenge, offering a potential strategy for vaccine development.
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May guide live-attenuated CSFV vaccine design; leaves open field efficacy and safety in swine.
Holinka et al. (2016) studied Classical swine fever virus (CSFV) infection. Recombinant CSFV with FPII mutations (W871T, W875D, V878T) vs. Wild-type Brescia virus (BICv) was evaluated on Virus replication in vitro and virulence in swine. Recombinant CSFV harboring amino acid substitutions W871T, W875D, and V878T in the E2 glycoprotein was completely attenuated in swine and protected animals against virulent challenge at 21 days.
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