July 27, 2004Socio-Environmental Systems ModelingOpen Access

Determinants of Virulence of Classical Swine Fever Virus Strain Brescia

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Structured PICO

Population

Pigs and in vitro cell models infected with classical swine fever virus (CSFV) strain Brescia clones (C1.1.1 and CoBrB)

Intervention

Chimeric viruses derived from C1.1.1 and CoBrB (476)R, and specific amino acid mutations (e.g., Leu to His at position 710 in E2, mutations in E(rns))

Comparator

Virulent variant CoBrB and other specific variants

Outcome

Virulence of CSFV in pigs and viral spread/infection efficiency in vitrosurrogate

Mutations in both E(rns) and E2 proteins are required to attenuate the virulence of classical swine fever virus strain Brescia in pigs.

Discussion

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Implication

Attenuates CSFV via E(rns)/E2 mutations in pigs; leaves open utility for live-attenuated vaccine design.

Cite This Study

Gennip et al. (2004) studied this question.

synapsesocial.com/papers/6a9276cf915bce628c4f3149 https://doi.org/10.1128/jvi.78.16.8812-8823.2004

View Full Paper

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Determinants of Virulence of Classical Swine Fever Virus Strain Brescia

Structured PICO

Discussion

Implication

Cite This Study

Determinants of Virulence of Classical Swine Fever Virus Strain Brescia

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider