Answers are grounded in this paper and cite their sources.
A 24-step synthesis of (±)-forskolin is presented, which delivered hundred milligram quantities of this complex diterpene in one pass. Transformations key to our approach include: a) a strategic allylic transposition, b) stepwise assembly of a sterically encumbered isoxazole ring, and c) citric acid-modified Upjohn dihydroxylation of a resilient tetrasubstituted olefin. The developed route has exciting potential for the preparation of new forskolin analogues inaccessible by semisynthesis.
No takes yet. Share an insight, caveat, or question.
Hylse et al. (2017) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: