Key result
Dabigatran use after primary joint replacement significantly increased post-operative wound leakage compared to a multimodal regimen (20% vs 5%; p<0.001).
Why the study?
Does dabigatran increase wound complications and thromboembolism compared to a multimodal regimen in patients undergoing primary joint replacement?
Population
1728 patients undergoing primary joint replacement
Comparison
Dabigatran for thromboprophylaxis vs Multimodal thromboprophylaxis regimen including…
Design
Cohort
Authors
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Dabigatran was associated with increased wound leakage after joint replacement; leaves open optimal thromboprophylaxis choice versus multimodal regimens.
Observational (n=1,728)
No
Does dabigatran increase wound complications and thromboembolism compared to a multimodal regimen in patients undergoing primary joint replacement?
Absolute Event Rate: 20% vs 5%
p-value: p=<0.001
Dabigatran for thromboprophylaxis after primary joint replacement is associated with increased wound leakage and higher VTE rates compared to a multimodal LMWH/aspirin regimen.
Bloch et al. (2014) conducted an observational in Primary joint replacement (n=1,728). Dabigatran vs. Multimodal regimen (low molecular weight heparin and extended aspirin) was evaluated on Post-operative wound leakage (p=<0.001). Dabigatran use after primary joint replacement significantly increased post-operative wound leakage compared to a multimodal regimen (20% vs 5%; p<0.001).
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