Key result
Regional anesthesia and analgesia reduced postoperative pain, morphine use, nausea, vomiting, and blood loss compared to general anesthesia and systemic analgesia, without impacting mortality.
Why the study?
Total hip and knee arthroplasty can benefit from regional anesthesia, but whether it reduces mortality, cardiovascular morbidity, thromboembolism, blood loss, and other perioperative outcomes remains to be determined.
Does regional anesthesia improve perioperative outcomes compared to general anesthesia in patients undergoing total hip and knee arthroplasty?
Population
Patients undergoing THA and TKA
Comparison
RA vs GA and systemic vs regional analgesia
Design
Systematic review of randomized controlled trials
Authors
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Regional anesthesia improves pain control and reduces opioid use in THA/TKA; reinforces secondary benefits without mortality or CV impact.
Systematic Review
Does regional anesthesia improve perioperative outcomes compared to general anesthesia in patients undergoing total hip and knee arthroplasty?
Regional anesthesia and analgesia improve pain management and reduce blood loss and opioid use in THA and TKA, though they do not significantly impact mortality or major cardiovascular events.
Chikkegowda et al. (2024) conducted a systematic review in Total hip arthroplasty (THA) and total knee arthroplasty (TKA). Regional anesthesia and regional analgesia vs. General anesthesia and systemic analgesia was evaluated on Mortality, cardiovascular morbidity, deep venous thrombosis, pulmonary embolism, blood loss, surgery duration, pain, opioid-related side effects, cognitive defects, and hospital stays. Regional anesthesia and analgesia reduced postoperative pain, morphine use, nausea, vomiting, and blood loss compared to general anesthesia and systemic analgesia, without impacting mortality.
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