Key result
Discharge on warfarin after total knee arthroplasty was associated with a 0.21% readmission rate compared with 1.05% for patients discharged without further anticoagulation.
Why the study?
Does extended warfarin therapy reduce readmission for venous thromboembolism or bleeding in patients undergoing total knee arthroplasty?
Population
1,321 patients undergoing total knee arthroplasty evaluated with prospective contrast venography from 1984…
Comparison
Extended warfarin therapy for 6 weeks after… vs No further anticoagulation after hospital…
Design
Cohort
Follow-up
6 months
Authors
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Warfarin at TKA discharge linked to fewer readmissions supports extended prophylaxis hypothesis; leaves open randomized confirmation before practice change.
Cohort (n=1,321)
Does extended warfarin therapy reduce readmission for venous thromboembolism or bleeding in patients undergoing total knee arthroplasty?
Absolute Event Rate: 0.21% vs 1.05%
Extended warfarin prophylaxis after hospital discharge following total knee arthroplasty reduces venous thromboembolism-related readmissions compared to no anticoagulation.
Pellegrini et al. (2006) conducted a cohort in Total knee arthroplasty (n=1,321). Warfarin vs. No further anticoagulation was evaluated on Readmission for deep venous thrombosis, pulmonary embolism, or bleeding. Discharge on warfarin after total knee arthroplasty was associated with a 0.21% readmission rate compared with 1.05% for patients discharged without further anticoagulation.
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