Why the study?
Does amethocaine spinal anaesthesia compared to general anaesthesia affect lower limb blood flow in men undergoing transurethral prostatectomy?
Does amethocaine spinal anaesthesia compared to general anaesthesia affect lower limb blood flow in men undergoing transurethral prostatectomy?
General anaesthesia is associated with a significant early postoperative reduction in lower limb blood flow compared to spinal anaesthesia, which may increase the risk of deep vein thrombosis.
General anaesthesia may increase early DVT risk after TURP; hypothesis-generating for spinal preference, requiring randomized confirmation.
Using venous occlusion impedance plethysmography, leg blood flow was measured in seventeen men undergoing transurethral prostatectomy under either amethocaine spinal anaesthesia (SAB) or nitrous oxide-halothane general anaesthesia (GA). Mean leg blood flow doubled (206% of pre-operative control value) following induction of SAB, remained elevated throughout surgery (146% of control at the end of operation) and had returned to pre-operative levels (94%) by two hours postoperatively. Under GA, mean blood flow rose gradually during surgery to 136% of control by the end. However, mean blood flow was only 28% of control at one hour postoperatively, rising to 66% of control by two hours. Analysis of variance showed a significant difference in blood flow changes between the two groups (Greenhouse Geisser P = 0.005). The early postoperative fall in leg blood flow in the GA group might be important in the aetiology of postoperative deep vein thrombosis.
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Foate et al. (1985) studied this question.
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