Key result
Genetic characterization of equine arteritis virus from carrier stallions over 5 years revealed highly conserved ORFs 1a, 1b, and 7, with substantial variation in ORFs 3 and 5.
Genetic variation in EAV during persistent infection occurs primarily in specific ORFs, but immune evasion and defective interfering particles are unlikely to be responsible for the establishment or maintenance of persistent infection in stallions.
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EAV persistence mechanisms in stallions remain unclear despite ORF variation; leaves open roles for other viral or host factors in future studies.
Balasuriya et al. (2004) studied Equine arteritis virus (EAV) persistent infection (n=10). Persistent EAV infection was evaluated on Viral genome sequence variation. Genetic characterization of equine arteritis virus from carrier stallions over 5 years revealed highly conserved ORFs 1a, 1b, and 7, with substantial variation in ORFs 3 and 5.
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