Adaptation of human rhinovirus type 2 to mouse cells is associated with altered nonstructural proteins, which may be involved in viral RNA synthesis and host range determination.
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Mouse-adapted rhinovirus data remain preclinical; leaves open nonstructural protein roles in host-range determination.
Human rhinovirus type 2 did not replicate in nonpermissive mouse cells; the restriction was not in adsorption but in the early events of virus replication. Mutants which had been adapted to grow in mouse cells had the following characteristics: (i) no change in the structural protein, (ii) a larger nonstructural protein and its precursor protein, and (iii) an altered viral RNA synthesis. The altered nonstructural proteins correlated with a change in host range of the virus and may be involved in viral RNA synthesis.
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Yin et al. (1983) studied this question.
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