Key result
Between 1998 and 2008 in Switzerland, the rate of percutaneous revascularizations for acute myocardial infarction increased significantly from 6.0% to 39.9%.
Observational (n=102,729)
Yes
Absolute Event Rate: 39.9% vs 6%
p-value: p=<0.001
A steep rise in revascularization procedures for AMI occurred in Switzerland between 1998 and 2008, which was associated with a decrease in unadjusted in-hospital mortality.
Increased PCI rates for AMI coincided with lower mortality; observational data leave causality open and should not yet change practice.
BACKGROUND: Since the late nineties, no study has assessed the trends in management and in-hospital outcome of acute myocardial infarction (AMI) in Switzerland. Our objective was to fill this gap. METHODS: Swiss hospital discharge database for years 1998 to 2008. AMI was defined as a primary discharge diagnosis code I21 according to the ICD10 classification. Invasive treatments and overall in-hospital mortality were assessed. RESULTS: Overall, 102,729 hospital discharges with a diagnosis of AMI were analyzed. The percentage of hospitalizations with a stay in an Intensive Care Unit decreased from 38.0% in 1998 to 36.2% in 2008 (p for trend < 0.001). Percutaneous revascularizations increased from 6.0% to 39.9% (p for trend < 0.001). Bare stents rose from 1.3% to 16.6% (p for trend < 0.001). Drug eluting stents appeared in 2004 and increased to 23.5% in 2008 (p for trend < 0.001). Coronary artery bypass graft increased from 1.0% to 3.0% (p for trend < 0.001). Circulatory assistance increased from 0.2% to 1.7% (p for trend < 0.001). Among patients managed in a single hospital (not transferred), seven-day and total in-hospital mortality decreased from 8.0% to 7.0% (p for trend < 0.01) and from 11.2% to 10.1%, respectively. These changes were no longer significant after multivariate adjustment for age, gender, region, revascularization procedures and transfer type. After multivariate adjustment, differing trends in revascularization procedures and in in-hospital mortality were found according to the geographical region considered. CONCLUSION: In Switzerland, a steep rise in hospital discharges and in revascularization procedures for AMI occurred between 1998 and 2008. The increase in revascularization procedures could explain the decrease in in-hospital mortality rates.
No takes yet. Share an insight, caveat, or question.
Insam et al. (2013) conducted an observational in Acute myocardial infarction (n=102,729). Year of hospital discharge (1998-2008) vs. 1998 (baseline year) was evaluated on Percutaneous revascularization rate (p=<0.001). Between 1998 and 2008 in Switzerland, the rate of percutaneous revascularizations for acute myocardial infarction increased significantly from 6.0% to 39.9%.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: