Key result
An elevated triglyceride glucose index (highest vs lowest tertile) was significantly associated with a more than two-fold increased risk of 3-vessel disease in patients with coronary heart disease (OR 2.27).
Why the study?
The triglyceride glucose index is a new marker associated with atherosclerosis, but its association with CAD severity in CHD patients across different glucose metabolic states needed assessment.
Does an elevated triglyceride glucose (TyG) index correlate with increased severity of coronary artery disease in patients with coronary heart disease?
Observational (n=731)
Yes
Does an elevated triglyceride glucose (TyG) index correlate with increased severity of coronary artery disease in patients with coronary heart disease?
Odds Ratio: 2.27 (95% CI 1.497–3.452)
p-value: p=<0.001
TyG index may flag greater CAD severity in CHD; leaves open its added value for risk stratification.
Abstract Background: The triglyceride glucose (TyG) index is a new marker associated with atherosclerosis. This study aimed to assess the association between the TyG index and the severity of coronary artery disease (CAD) in patients with coronary heart disease (CHD) and further explore the association between the TyG index and CAD severity in different glucose metabolic states.Methods: This multi-centre retrospective study included 731 CHD patients between September 1, 2014 to September 30, 2020 in China. All patients were stratified into groups based on the tertiles of the TyG index (T1:5.48 ≤ TyG index ≤ 7.17; T2: 7.18 ≤ TyG ≤ 7.76; T3: 7.77 ≤ TyG ≤ 10.82) and the number of diseased vessels [1-vessel disease (VD), 2-VD and 3-VD] represented the severity of CAD. The relationship between the TyG index and CAD severity was analysed using logistic regression. The associations between the TyG index and CAD severity based on different glucose metabolic status were also assessed. Receiver operating characteristic (ROC) curves were performed to evaluate the accuracy of the TyG index for detecting the CAD severity.Results: The baseline analysis results showed significant differences in clinical and biological characteristics of CHD patients according to the TyG index tertiles (P < 0.05 to < 0.001). The TyG index was significantly related to the risk of multiple diseased coronary arteries and more severe coronary stenoses (CS) (P < 0.001). The TyG index was significantly associated with the risk of 3-VD in patients with CHD. The odds ratio (OR) of 3-VD for the TyG index T3 compared to T1 was 2.27 (95% confidence interval [CI] 1.497-3.452; P for trend <0.001). Among different states of glucose metabolism, the association between the TyG index and 3-VD observed was significant in diabetes (OR: 1.662; 95% CI 1.166–2.369). A TyG index threshold for predicting 3-VD (95% [CI] 0.554-0.664; P < 0.001 ) was 7.0 and was 8.1 in diabetes state (95% [CI] 0.523-0.646; P < 0.001 ).Conclusion: The TyG index is associated with CAD severity in CHD patients and an increased TyG index could identify CHD patients with a high risk of 3-VD. The association between the TyG index and CAD severity in the condition of diabetes is higher than in non-diabetes.
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Su et al. (2022) conducted an observational in Coronary heart disease (n=731). Triglyceride glucose (TyG) index vs. Lowest TyG index tertile (T1) was evaluated on Risk of 3-vessel disease (3-VD) (OR 2.27, 95% CI 1.497-3.452, p=<0.001). An elevated triglyceride glucose index (highest vs lowest tertile) was significantly associated with a more than two-fold increased risk of 3-vessel disease in patients with coronary heart disease (OR 2.27).
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