Why the study?
Does daunorubicin accelerate marrow disease clearance and improve disease-free survival in children with lymphoblastic leukaemia?
Population
1419 children with childhood lymphoblastic leukaemia (ALL) enrolled in the UKALL XI national MRC trial
Comparison
Bolus of daunorubicin on the first 2 days of the… vs No daunorubicin
Design
Cohort, Central review of marrow status
Authors
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Early marrow clearance with daunorubicin does not improve survival; leaves open the prognostic value of blast clearance in paediatric ALL.
Does daunorubicin accelerate marrow disease clearance and improve disease-free survival in children with lymphoblastic leukaemia?
While daunorubicin accelerates early marrow blast clearance in childhood ALL, this faster initial response does not translate to improved disease-free or relapse-free survival.
Lilleyman et al. (1997) studied this question.
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