Key result
Coffee consumption significantly increased superoxide dismutase (SOD) enzyme levels compared to hyperlipidemia alone (8.3 vs 7.2 ng/ml, p=0.006) in male Wistar rats.
Why the study?
Atherosclerosis and ischemic stroke are linked to oxidative stress from ROS induced by hyperlipidemia, and coffee contains antioxidant chlorogenic acid capable of inhibiting ROS formation.
Does coffee consumption increase superoxide dismutase (SOD) enzyme expression in Wistar rats induced with hyperlipidemia?
Does coffee consumption increase superoxide dismutase (SOD) enzyme expression in Wistar rats induced with hyperlipidemia?
In a rat model of hyperlipidemia, coffee consumption significantly increased the antioxidant enzyme superoxide dismutase (SOD) and decreased cholesterol levels.
Answers are grounded in this paper and cite their sources.
May support antioxidant effects of coffee in hyperlipidemic rat models; hypothesis-generating with no implications for human practice.
One of the causes of stroke is atherosclerosis. The incidence of occurrence ischemic stroke caused by atherosclerosis is 95%. Atherosclerosis is caused by oxidative stress in the endothelium due to the formation of Reactive Oxygen Species (ROS). Hyperlipidemia (hyper LDL) is one of the risk factors of elevated ROS. One of the enzymes that play a role in preventing the formation of ROS is superoxide dismutase (SOD). Coffee has a powerful antioxidant in which one of its active ingredients is chlorogenic acid that capable to inhibiting ROS formation. Fifteen wistar male divided into 3 groups. Group I (Control) were given standard fed, Group II (Hyperlipidemia) were given standart fed and hyperlipid diet, Group III (Coffee) were given standart fed and hyperlipid diet + coffee consumption. Treatment were done everyday for 30 days. Blood serum in each group was taken on day 30 and examined by ELISA superoxide dismutase (SOD). The results showed that superoxide dismutase levels in coffee group was significantly higher than hyperlipidemia group (p = 0,006). This study proves that coffee consumption can increase the production of superoxide dismutase enzyme. Keywords: atherosclerosis; coffee; hyperlipid; SOD
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Prasetya et al. (2020) studied Hyperlipidemia (n=15). Coffee vs. Hyperlipidemia diet alone was evaluated on Superoxide dismutase (SOD) level (p=0.006). Coffee consumption significantly increased superoxide dismutase (SOD) enzyme levels compared to hyperlipidemia alone (8.3 vs 7.2 ng/ml, p=0.006) in male Wistar rats.
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