Key result
A novel recombinant of CV-A5, featuring a recombination with CV-A2 at the 2A region, emerged as one of the major pathogens responsible for the 2016-2017 hand, foot, and mouth disease epidemic in Xiangyang, China.
Why the study?
Hand, foot and mouth disease is caused by various enterovirus serotypes, and the worldwide etiological spectrum has been changing since large-scale outbreaks in 1997.
Observational (n=3,703)
A novel recombinant of CV-A5 and CV-A2 emerged as a major pathogen in the 2016-2017 HFMD epidemic in Xiangyang, China, highlighting the role of recombination in enterovirus evolution.
Novel recombinants may fuel HFMD outbreaks; leaves open needs for genomic surveillance and cardiac complication tracking.
Hand, foot and mouth disease (HFMD) is caused by a variety of enterovirus serotypes and the etiological spectrum worldwide has been changing since a large scale of outbreaks occurred in 1997. A large number of clinical specimens of HFMD patients were collected in Xiangyang and genotyping was performed by qRT-PCR, conventional PCR amplification and sequencing. Among the146 CV-A5 cases detected, the complete genome sequences of representative strains were determined for genotyping and for recombination analysis. It was found that CV-A5 was one of the six major serotypes that caused the epidemic from October 2016 to December 2017. Phylogenetic analyses based on the VP1 sequences showed that these CV-A5 belong to the genotype D which dominantly circulates in China. Recombination occurred between the CV-A5 and CV-A2 strains with a breakpoint at the nt position 3,791 in the 2A region. The result may explain the emergence of CV-A5 as one of the major pathogens of HFMD.
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Yu et al. (2021) conducted an observational in Hand, foot and mouth disease (HFMD) (n=3,703). CV-A5 was evaluated on Detection and genetic characterization of CV-A5. A novel recombinant of CV-A5, featuring a recombination with CV-A2 at the 2A region, emerged as one of the major pathogens responsible for the 2016-2017 hand, foot, and mouth disease epidemic in Xiangyang, China.
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