Key result
EV71 (subgenotype C4) and CVA16 (clusters B2a and B2b) were the major etiological agents of hand, foot and mouth disease, detected in 38.4% and 35.4% of enterovirus-positive cases, respectively.
Population
399 stool specimens from children with symptoms of hand, foot and mouth disease in Zhejiang Province, China
Design
Cross-sectional
Authors
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Supports regional HFMD strain surveillance in China; leaves open links to severity or vaccine matching pending prospective data.
Cross-Sectional (n=399)
No
The study identifies the endemic circulation patterns of EV71 subgenotype C4 and CVA16 genotype B2 clusters in children with HFMD in China.
Chen et al. (2012) conducted a cross-sectional in Hand, foot and mouth disease (HFMD) (n=399). Enterovirus 71 and Coxsackievirus A16 was evaluated on Detection rate of EV71 and CVA16 in HEV-A species-positive cases. EV71 (subgenotype C4) and CVA16 (clusters B2a and B2b) were the major etiological agents of hand, foot and mouth disease, detected in 38.4% and 35.4% of enterovirus-positive cases, respectively.
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