Key result
Other β-lactam antibacterials were the most commonly prescribed antimicrobials (40.85%), and there was a significant increase in the number of drugs prescribed to patients with impaired renal function compared to those with normal renal function (p <0.05).
Observational (n=165)
No
p-value: p=<0.05
In elderly diabetic and hypertensive inpatients, polypharmacy and antimicrobial use are significantly higher in those with impaired renal function, highlighting the need for careful prescription and dosage adjustment.
May warrant closer renal dosing review in elderly inpatients; leaves open whether stewardship reduces adverse events in comorbid populations.
Background: Hypertension (HTN) and diabetes mellitus (DM) are the primary contributors to renovascular mortality and morbidity including chronic kidney diseases. Additionally, these patients are in frequent need of an antimicrobial agent. Drug utilisation studies (DUS) are prospective tools in the assessment of health care systems. The objective of the present study was to analyse the prescription pattern of anti-microbials in elderly hypertensive diabetic in-patients with or without renal impairment in a tertiary hospitalMethods: The study population comprised of 165 hypertensive diabetic in-patients at Shri Dharmasthala Manjunatheshwara (SDM) Hospital. Questionnaire based evaluation was carried out and prescriptions of patient with HTN and DM at and above the age of 60 years irrespective of gender were included.Results: Among anti-microbial agents, other β lactam antibacterial were the most commonly prescribed class of drugs (40.85%) which was similar in patients with impaired renal function (21.8%).Conclusions: There was a significant increase in the number of anti-microbial agents and other drugs in the patients with impaired renal function when compared to patients with normal renal function (p <0.05).
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Bhandari et al. (2018) conducted an observational in Hypertension and diabetes mellitus (n=165). Antimicrobial agents was evaluated on Prescription pattern of anti-microbials and number of drugs used (p=<0.05). Other β-lactam antibacterials were the most commonly prescribed antimicrobials (40.85%), and there was a significant increase in the number of drugs prescribed to patients with impaired renal function compared to those with normal renal function (p <0.05).
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