Key result
Endothelial dysfunction is strongly associated with the pathological development and progression of kidney impairment to renal failure.
Endothelial dysfunction, characterized by impaired vasorelaxation and increased oxidative stress, plays a significant role in the progression of kidney disease to renal failure.
Supports endothelial assessment in CKD progression; leaves open causality and need for interventional trials.
Endothelial dysfunction is principally characterized by impaired endothelium- dependent transduction mechanisms related to vascular relaxation, as an outcome of decreased release of endothelium-derived relaxing factors, mainly nitric oxide, as well as augmented oxidative stress, increased inflammation and predominance of vascular action produced by endothelium-derived contracting factors. Current data strongly suggest that pathological development of different types of kidney impairment with further progression to renal failure includes notable vascular changes associated with endothelial dysfunction. In accordance, this scientific field represents an advancing area of investigation, involving different biomarkers of endothelial dysfunction linked to renal impairment, as well as clinical findings with new information that can provide a more comprehensive understanding of the role of endothelial dysfunction in kidney disease. With regards to quoted facts, the aim of this article was to review the latest data related to endothelial dysfunction and renal failure by selection of relevant articles released from 2010 to 2015.
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Radenković et al. (2015) conducted a review in Renal failure. Endothelial dysfunction was evaluated. Endothelial dysfunction is strongly associated with the pathological development and progression of kidney impairment to renal failure.
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